Cancer Genome Atlas Identifies Distinct Subtypes of the Brain Cancer Glioblastoma Multiforme

Gliobastoma (astrocytoma) WHO grade IV - MRI coronal view, post contrast. 15 year old boy;Image via Wikipedia

Another Article on Glioblastoma Multiforme that I’ve written on scientificblogging.com!

The most common form of  brain tumor in adults, glioblastoma multiforme (GBM), is not in fact a single disease but appears to be four distinct molecular subtypes, according to a study by The Cancer Genome Atlas (TCGA) Research Network. The researchers in this study also found that response to aggressive chemotherapy and radiation differed by subtype.The research team for TCGA is a collaborative effort funded by the National Cancer Institute (NCI) and the National Human Genome Research Institute (NHGRI), both parts of the National Institutes of Health. The Cancer Genome Atlas (TCGA) aims to catalogue and discover major cancer-causing genome alterations in large cohorts of human tumours through integrated multi-dimensional analyses.(3)The study, published Jan. 19, 2010 in Cancer Cell, provides a solid framework for investigation of targeted therapies that may improve the near uniformly fatal prognosis of this cancer.Although the findings do not affect current clinical practice, the researchers said the results may lead to more personalized approaches to treating groups of GBM patients based on their genomic alterations.Rest of article can be read by following the link below.

http://www.scientificblogging.com/biochem_geek/blog/cancer_genome_atlas_identifies_distinct_subtypes_brain_cancer_glioblastoma_multiforme